CATH Domain 4c7kB00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Corticosteroid 11-beta-dehydrogenase isozyme 1

Enzyme Information

1.1.1.146

11-beta-hydroxysteroid dehydrogenase.

based on mapping to UniProt P28845

An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH.

UniProtKB Entries (1)

DHI1_HUMAN

Homo sapiens

Corticosteroid 11-beta-dehydrogenase isozyme 1

PDB Structure

PDB	4C7K
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Optimization of Brain Penetrant 11Beta-Hydroxysteroid Dehydrogenase Type I Inhibitors and in Vivo Testing in Diet- Induced Obese Mice. Goldberg, F.W., Dossetter, A.G., Scott, J.S., Robb, G.R., Boyd, S., Groombridge, S.D., Kemmitt, P.D., Sjogren, T., Gutierrez, P.M., Deschoolmeester, J., Swales, J.G., Turnbull, A.V., Wild, M.J. J.Med.Chem.