CATH Domain 4c5fA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.530	Lysozyme
	1.10.530.10

Domain Context

CATH Clusters

Superfamily	1.10.530.10
Functional Family	Membrane-bound lytic murein transglycosylase C

Enzyme Information

4.2.2.n1

Peptidoglycan lytic exotransglycosylase.

based on mapping to UniProt P0C066

Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.

UniProtKB Entries (1)

P0C066

MLTC_ECOLI

Escherichia coli K-12

Membrane-bound lytic murein transglycosylase C

PDB Structure

PDB	4C5F
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure and Cell Wall Cleavage by Modular Lytic Transglycosylase Mltc of Escherichia Coli. Artola-Recolons, C., Lee, M., Bernardo-Garcia, N., Blazquez, B., Hesek, D., Bartual, S.G., Mahasenan, K.V., Lastochkin, E., Pi, H., Boggess, B., Meindl, K., Uson, I., Fisher, J.F., Mobashery, S., Hermoso, J.A. Acs Chem.Biol.