CATH Domain 4c4jA01

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Dual specificity protein kinase TTK

2.7.12.1

Dual-specificity kinase.

based on mapping to UniProt P33981

ATP + a protein = ADP + a phosphoprotein.

-!- This family of enzymes can phosphorylate both Ser/Thr and Tyr residues. -!- Formerly EC 2.7.1.37.

TTK_HUMAN

Homo sapiens

Dual specificity protein kinase TTK

PDB	4C4J
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Based Design of Orally Bioavailable 1H-Pyrrolo[3, 2-C]Pyridine Inhibitors of the Mitotic Kinase Monopolar Spindle 1 (Mps1). Naud, S., Westwood, I.M., Faisal, A., Sheldrake, P.W., Bavetsias, V., Atrash, B., Cheung, K.J., Liu, M., Hayes, A., Schmitt, J., Wood, A., Choi, V., Boxall, K., Mak, G., Gurden, M., Valenti, M., De-Haven-Brandon, A., Henley, A., Baker, R., Mcandrew, C., Matijssen, B., Burke, R., Hoelder, S., Eccles, S.A., Raynaud, F.I., Linardopoulos, S., Van Montfort, R.L.M., Blagg, J. J.Med.Chem.