CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Aurora kinase A

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O14965
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O14965
AURKA_HUMAN
Homo sapiens
Aurora kinase A

PDB Structure

PDB 4C3P
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Molecular Mechanism of Aurora a Kinase Autophosphorylation and its Allosteric Activation by Tpx2.
Zorba, A., Buosi, V., Kutter, S., Kern, N., Pontiggia, F., Cho, Y.J., Kern, D.
Elife