CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P06239
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P06239
LCK_HUMAN
Homo sapiens
Tyrosine-protein kinase Lck

PDB Structure

PDB 4C3F
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Efficient search of chemical space: navigating from fragments to structurally diverse chemotypes.
Wassermann, A.M., Kutchukian, P.S., Lounkine, E., Luethi, T., Hamon, J., Bocker, M.T., Malik, H.A., Cowan-Jacob, S.W., Glick, M.
J. Med. Chem.