CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.90 | Alpha-Beta Complex | |
3.90.190 | Protein-Tyrosine Phosphatase; Chain A | |
3.90.190.20 | Mur ligase, C-terminal domain |
Domain Context
CATH Clusters
Superfamily | Mur ligase, C-terminal domain |
Functional Family |
Enzyme Information
6.3.2.7 |
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase.
based on mapping to UniProt Q2FZP6
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate + L-lysine = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D- glutamyl-L-lysine.
-!- Involved in the synthesis of a cell-wall peptide. -!- This enzyme adds lysine in some Gram-positive organisms; in others and in Gram-negative organisms EC 6.3.2.13 adds 2,6-diaminopimelate instead.
|
UniProtKB Entries (1)
Q2FZP6 |
MURE_STAA8
Staphylococcus aureus subsp. aureus NCTC 8325
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase
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PDB Structure
PDB | 4C13 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Specificity Determinants for Lysine Incorporation in Staphylococcus Aureus Peptidoglycan as Revealed by the Structure of a Mure Enzyme Ternary Complex.
J.Biol.Chem.
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