CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.70 | Distorted Sandwich | |
2.70.98 | Beta-galactosidase; Chain A, domain 5 | |
2.70.98.20 | Copper amine oxidase, catalytic domain |
Domain Context
CATH Clusters
Superfamily | Copper amine oxidase, catalytic domain |
Functional Family |
Enzyme Information
1.4.3.21 |
Primary-amine oxidase.
based on mapping to UniProt Q16853
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
-!- A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1). -!- Formerly EC 1.4.3.6.
|
UniProtKB Entries (1)
Q16853 |
AOC3_HUMAN
Homo sapiens
Membrane primary amine oxidase
|
PDB Structure
PDB | 4BTW |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Novel Pyridazinone Inhibitors for Vascular Adhesion Protein- 1 (Vap-1): Old Target - New Inhibition Mode.
J.Med.Chem.
|