CATH Domain 4bfdA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.70	Cathepsin D, subunit A; domain 1
	2.40.70.10	Acid Proteases

Domain Context

CATH Clusters

Superfamily	Acid Proteases
Functional Family	Beta-secretase 1

Enzyme Information

3.4.23.46

Memapsin 2.

based on mapping to UniProt P56817

Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu- Phe in the Swedish variant of Alzheimer's amyloid precursor protein.

-!- Suggested to be the major 'beta-secretase' responsible for the cleavage of the beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease. -!- Belongs to peptidase family A1.

UniProtKB Entries (1)

P56817

BACE1_HUMAN

Homo sapiens

Beta-secretase 1

PDB Structure

PDB	4BFD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Bace1 Inhibitors: A Head Group Scan on a Series of Amides. Woltering, T.J., Wostl, W., Hilpert, H., Rogers-Evans, M., Pinard, E., Mayweg, A., Gobel, M., Banner, D.W., Benz, J., Travagli, M., Pollastrini, M., Marconi, G., Gabellieri, E., Guba, W., Mauser, H., Andreini, M., Jacobsen, H., Power, E., Narquizian, R. Bioorg.Med.Chem.Lett.