CATH Domain 4be0A01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.340	Endonuclease III; domain 1
	1.10.340.70

Domain Context

CATH Clusters

Superfamily	1.10.340.70
Functional Family	Pro-Pol polyprotein

Enzyme Information

3.1.-.-	Acting on ester bonds. based on mapping to UniProt P14350
3.4.23.-	Aspartic endopeptidases. based on mapping to UniProt P14350
2.7.7.49	RNA-directed DNA polymerase. based on mapping to UniProt P14350 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
3.1.26.4	Ribonuclease H. based on mapping to UniProt P14350 Endonucleolytic cleavage to 5'-phosphomonoester. -!- Acts on RNA-DNA hybrids.
2.7.7.7	DNA-directed DNA polymerase. based on mapping to UniProt P14350 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
2.7.7.-	Nucleotidyltransferases. based on mapping to UniProt P14350

UniProtKB Entries (1)

POL_FOAMV

Human spumaretrovirus

Pro-Pol polyprotein

PDB Structure

PDB	4BE0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Activities, Crystal Structures and Molecular Dynamics of Dihydro-1H-Isoindole Derivatives, Inhibitors of HIV-1 Integrase. Metifiot, M., Maddali, K., Johnson, B.C., Hare, S., Smith, S.J., Zhao, X.Z., Marchand, C., Burke, T.R., Hughes, S.H., Cherepanov, P., Pommier, Y. Acs Chem.Biol.