CATH Domain 4b04A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.190	Protein-Tyrosine Phosphatase; Chain A
	3.90.190.10	Protein tyrosine phosphatase superfamily

Domain Context

CATH Clusters

Superfamily	Protein tyrosine phosphatase superfamily
Functional Family	dual specificity protein phosphatase 26

Enzyme Information

3.1.3.48

Protein-tyrosine-phosphatase.

based on mapping to UniProt Q9BV47

Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

3.1.3.16

Protein-serine/threonine phosphatase.

based on mapping to UniProt Q9BV47

[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.

-!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).

UniProtKB Entries (1)

Q9BV47

DUS26_HUMAN

Homo sapiens

Dual specificity protein phosphatase 26

PDB Structure

PDB	4B04
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	High-Resolution Crystal Structure of the Catalytic Domain of Human Dual-Specificity Phosphatase 26 Won, E.-Y., Xie, Y., Takemoto, C., Chen, L., Liu, Z.-J., Wang, B.C., Lee, D., Woo, E.-J., Park, S.G., Shirouzu, M., Yokoyama, S., Kim, S.J., Chi, S.-W. Acta Crystallogr.,Sect.D