CATH Domain 4az3A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.1820	alpha/beta hydrolase

Domain Context

CATH Clusters

Superfamily	alpha/beta hydrolase
Functional Family	Carboxypeptidase

Enzyme Information

3.4.16.5

Carboxypeptidase C.

based on mapping to UniProt P10619

Release of a C-terminal amino acid with broad specificity.

-!- Carboxypeptidases of broad specificity with optimum pH 4.5-6.0, inhibited by the action of diisopropyl fluorophosphate, and sensitive to thiol-blocking reagents. -!- This enzyme is probably also identical to lysosomal tyrosine carboxypeptidase. -!- Belongs to peptidase family S10. -!- Formerly EC 3.4.12.1, EC 3.4.12.12, EC 3.4.16.1, EC 3.4.16.3 and EC 3.4.21.13.

UniProtKB Entries (1)

P10619

PPGB_HUMAN

Homo sapiens

Lysosomal protective protein

PDB Structure

PDB	4AZ3
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Novel Beta-Amino Acid Derivatives as Inhibitors of Cathepsin A. Ruf, S., Buning, C., Schreuder, H., Horstick, G., Linz, W., Olpp, T., Pernerstorfer, J., Hiss, K., Kroll, K., Kannt, A., Kohlmann, M., Linz, D., Hubschle, T., Rutten, H., Wirth, K., Schmidt, T., Sadowski, T. J.Med.Chem.