CATH Domain 4axeA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.110	Inositol-pentakisphosphate 2-kinase, N-lobe

Domain Context

CATH Clusters

Superfamily	Inositol-pentakisphosphate 2-kinase, N-lobe
Functional Family	Inositol-pentakisphosphate 2-kinase

Enzyme Information

2.7.1.158

Inositol-pentakisphosphate 2-kinase.

based on mapping to UniProt Q93YN9

ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate.

-!- The enzyme can also use Ins(1,4,5,6)P(4) and Ins(1,4,5)P(3) as substrate. -!- Inositol hexakisphosphate (phytate) accumulates in storage protein bodies during seed development and, when hydrolyzed, releases stored nutrients to the developing seedling before the plant is capable of absorbing nutrients from its environment.

UniProtKB Entries (1)

Q93YN9

IPPK_ARATH

Arabidopsis thaliana

Inositol-pentakisphosphate 2-kinase

PDB Structure

PDB	4AXE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Conformational Changes Undergone by Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase Upon Substrate Binding: The Role of N-Lobe and Enantiomeric Substrate Preference Banos-Sanz, J.I., Sanz-Aparicio, J., Whitfield, H., Hamilton, C., Brearley, C.A., Gonzalez, B. J.Biol.Chem.