CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.200 | Phosphorylase Kinase; domain 1 |
|
3.30.200.110 | Inositol-pentakisphosphate 2-kinase, N-lobe |
Domain Context
CATH Clusters
| Superfamily | Inositol-pentakisphosphate 2-kinase, N-lobe |
| Functional Family | Inositol-pentakisphosphate 2-kinase |
Enzyme Information
| 2.7.1.158 |
Inositol-pentakisphosphate 2-kinase.
based on mapping to UniProt Q93YN9
ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + 1D-myo-inositol hexakisphosphate.
-!- The enzyme can also use Ins(1,4,5,6)P(4) and Ins(1,4,5)P(3) as substrate. -!- Inositol hexakisphosphate (phytate) accumulates in storage protein bodies during seed development and, when hydrolyzed, releases stored nutrients to the developing seedling before the plant is capable of absorbing nutrients from its environment.
|
UniProtKB Entries (1)
| Q93YN9 |
IPPK_ARATH
Arabidopsis thaliana
Inositol-pentakisphosphate 2-kinase
|
PDB Structure
| PDB | 4AXD |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Conformational Changes Undergone by Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinase Upon Substrate Binding: The Role of N-Lobe and Enantiomeric Substrate Preference
J.Biol.Chem.
|