CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.20 | Alpha-Beta Barrel |
|
3.20.20 | TIM Barrel |
|
3.20.20.70 | Aldolase class I |
Domain Context
CATH Clusters
| Superfamily | Aldolase class I |
| Functional Family |
Enzyme Information
| 4.1.3.3 |
N-acetylneuraminate lyase.
based on mapping to UniProt Q2G160
N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate.
-!- Also acts on N-glycoloylneuraminate, and on O-acetylated sialic acids, other than 4-O-acetylated derivatives.
|
UniProtKB Entries (1)
| Q2G160 |
NANA_STAA8
Staphylococcus aureus subsp. aureus NCTC 8325
N-acetylneuraminate lyase
|
PDB Structure
| PDB | 4AMA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural insights into the recovery of aldolase activity in N-acetylneuraminic acid lyase by replacement of the catalytically active lysine with gamma-thialysine by using a chemical mutagenesis strategy.
Chembiochem
|
