CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family

Enzyme Information

1.3.1.39
Enoyl-[acyl-carrier-protein] reductase (NADPH, Re-specific).
based on mapping to UniProt A0A0H3JLH9
An acyl-[acyl-carrier protein] + NADP(+) = a trans-2,3-dehydroacyl-[acyl- carrier protein] + NADPH.
-!- This enzyme completes each cycle of fatty acid elongation by catalyzing the stereospecific reduction of the double bond at position 2 of a growing fatty acid chain, while linked to an acyl- carrier protein. -!- It is one of the activities of EC 2.3.1.85. -!- The mammalian enzyme is Re-specific with respect to NADP(+) (cf. EC 1.3.1.10 and and EC 1.3.1.104).

UniProtKB Entries (1)

A0A0H3JLH9
A0A0H3JLH9_STAAN
Staphylococcus aureus subsp. aureus N315
Enoyl-[acyl-carrier-protein] reductase [NADPH]

PDB Structure

PDB 4ALN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Staphylococcus Aureus Fabi: Inhibition, Substrate Recognition and Potential Implications for in Vivo Essentiality
Schiebel, J., Chang, A., Lu, H., Baxter, M.V., Tonge, P.J., Kisker, C.
Structure
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