CATH Domain 4ai9A01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.650	Cupin

Domain Context

CATH Clusters

Superfamily	Cupin
Functional Family	Lysine-specific demethylase 4A

Enzyme Information

1.14.11.-

With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.

based on mapping to UniProt O75164

UniProtKB Entries (1)

KDM4A_HUMAN

Homo sapiens

Lysine-specific demethylase 4A

PDB Structure

PDB	4AI9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. Rose, N.R., Woon, E.C., Tumber, A., Walport, L.J., Chowdhury, R., Li, X.S., King, O.N., Lejeune, C., Ng, S.S., Krojer, T., Chan, M.C., Rydzik, A.M., Hopkinson, R.J., Che, K.H., Daniel, M., Strain-Damerell, C., Gileadi, C., Kochan, G., Leung, I.K., Dunford, J., Yeoh, K.K., Ratcliffe, P.J., Burgess-Brown, N., von Delft, F., Muller, S., Marsden, B., Brennan, P.E., McDonough, M.A., Oppermann, U., Klose, R.J., Schofield, C.J., Kawamura, A. J. Med. Chem.