CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Tyrosine-protein kinase

Enzyme Information

2.7.10.2
Non-specific protein-tyrosine kinase.
based on mapping to UniProt P00523
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- Unlike EC 2.7.10.1, this protein-tyrosine kinase does not have a transmembrane domain. -!- In the human genome, 32 non-specific protein-tyrosine kinases have been identified and these can be divided into 10 families. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P00523
SRC_CHICK
Gallus gallus
Proto-oncogene tyrosine-protein kinase Src

PDB Structure

PDB 4AGW
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of a Small-Molecule Type II Inhibitor of Wild-Type and Gatekeeper Mutants of Bcr-Abl, Pdgfralpha, Kit, and Src Kinases: Novel Type II Inhibitor of Gatekeeper Mutants.
Weisberg, E., Choi, H.G., Ray, A., Barrett, R., Zhang, J., Sim, T., Zhou, W., Seeliger, M., Cameron, M., Azam, M., Fletcher, J.A., Debiec-Rychter, M., Mayeda, M., Moreno, D., Kung, A.L., Janne, P.A., Khosravi-Far, R., Melo, J.V., Manley, P.W., Adamia, S., Wu, C., Gray, N., Griffin, J.D.
Blood