CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.80 | Trefoil |
|
2.80.10 | Trefoil (Acidic Fibroblast Growth Factor, subunit A) |
|
2.80.10.50 |
Domain Context
CATH Clusters
| Superfamily | 2.80.10.50 |
| Functional Family | Aldos-2-ulose dehydratase |
Enzyme Information
| 4.2.1.110 |
Aldos-2-ulose dehydratase.
based on mapping to UniProt P84193
1,5-anhydro-D-fructose = 2-hydroxy-2-(hydroxymethyl)-2H-pyran-3(6H)-one + H(2)O.
-!- This enzyme catalyzes two of the steps in the anhydrofructose pathway, which leads to the degradation of glycogen and starch via 1,5-anhydro-D-fructose. -!- Aldose-2-uloses such as 2-dehydroglucose can also act as substrates, but more slowly. -!- This is a bifunctional enzyme that acts as both a lyase and as an isomerase. -!- Differs from EC 4.2.1.111, which can carry out only reaction 1, is inhibited by its product and requires metal ions for activity.
|
UniProtKB Entries (1)
| P84193 |
AUD_PHACH
Phanerochaete chrysosporium
Aldos-2-ulose dehydratase
|
PDB Structure
| PDB | 4A7Y |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure of Bifunctional Aldos-2-Ulose Dehydratase/Isomerase from Phanerochaete Chrysosporium with the Reaction Intermediate Ascopyrone M.
J.Mol.Biol.
|
