CATH Domain 4a73A02

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.110	L-2-Hydroxyisocaproate Dehydrogenase; Chain A, domain 2
	3.90.110.10	Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal

Superfamily	Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Functional Family

1.1.1.27

L-lactate dehydrogenase.

based on mapping to UniProt Q5SJA1

(S)-lactate + NAD(+) = pyruvate + NADH.

-!- Also oxidizes other (S)-2-hydroxymonocarboxylic acids. -!- NADP(+) acts, more slowly, with the animal, but not the bacterial, enzyme.

LDH_THET8

Thermus thermophilus HB8

L-lactate dehydrogenase

PDB	4A73
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Sampling the Conformational Energy Landscape of a Hyperthermophilic Protein by Engineering Key Substitutions Colletier, J.P., Aleksandrov, A., Coquelle, N., Mraihi, S., De Mendoza-Barbera, E., Field, M., Madern, D. Mol.Biol.Evol.