CATH Domain 4a6lA02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.10	Thrombin, subunit H
	2.40.10.10	Trypsin-like serine proteases

Domain Context

CATH Clusters

Superfamily	Trypsin-like serine proteases
Functional Family	Tryptase gamma 1

Enzyme Information

3.4.21.59

Tryptase.

based on mapping to UniProt Q15661

Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa, but with more restricted specificity than trypsin.

-!- Occurs as a tetrameric molecule with high affinity for heparin, in mast cell granules. -!- Not inhibited by alpha-1-proteinase inhibitor of alpha-2- macroglobulin. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

Q15661

TRYB1_HUMAN

Homo sapiens

Tryptase alpha/beta-1

PDB Structure

PDB	4A6L
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Based Library Design and the Discovery of a Potent and Selective Mast Cell Beta-Tryptase Inhibitor as an Oral Therapeutic Agent. Liang, G., Aldous, S., Merriman, G., Levell, J., Pribish, J., Cairns, J., Chen, X., Maignan, S., Mathieu, M., Tsay, J., Sides, K., Rebello, S., Whitely, B., Morize, I., Pauls, H.W. Bioorg.Med.Chem.Lett.