CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.1170 | Aldehyde Oxidoreductase; domain 3 |
|
3.90.1170.50 | Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead |
Domain Context
CATH Clusters
| Superfamily | Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead |
| Functional Family | Aldehyde oxidase 1 |
Enzyme Information
| 1.17.3.- |
With oxygen as acceptor.
based on mapping to UniProt G3X982
|
| 1.2.3.1 |
Aldehyde oxidase.
based on mapping to UniProt G3X982
An aldehyde + H(2)O + O(2) = a carboxylate + H(2)O(2).
-!- The enzyme from liver exhibits a broad substrate specificity, and is involved in the metabolism of xenobiotics, including the oxidation of N-heterocycles and aldehydes and the reduction of N-oxides, nitrosamines, hydroxamic acids, azo dyes, nitropolycyclic aromatic hydrocarbons, and sulfoxides. -!- The enzyme is also responsible for the oxidation of retinal, an activity that was initially attributed to a distinct enzyme (EC 1.2.3.11). -!- Formerly EC 1.2.3.11.
|
UniProtKB Entries (1)
| G3X982 |
AOXC_MOUSE
Mus musculus
Aldehyde oxidase 3
|
PDB Structure
| PDB | 3ZYV |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The First Mammalian Aldehyde Oxidase Crystal Structure: Insights Into Substrate Specificity.
J.Biol.Chem.
|
