CATH Domain 3zyuA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.920	Histone Acetyltransferase; Chain A
	1.20.920.10	Bromodomain-like

Domain Context

CATH Clusters

Superfamily	Bromodomain-like
Functional Family	Bromodomain-containing protein 4

Enzyme Information

UniProtKB Entries (1)

BRD4_HUMAN

Homo sapiens

Bromodomain-containing protein 4

PDB Structure

PDB	3ZYU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Inhibition of Bet Recruitment to Chromatin as an Effective Treatment for Mll-Fusion Leukaemia. Dawson, M.A., Prinjha, R.K., Dittman, A., Giotopoulos, G., Bantscheff, M., Chan, W.I., Robson, S.C., Chung, C.W., Hopf, C., Savitski, M.M., Huthmacher, C., Gudgin, E., Lugo, D., Beinke, S., Chapman, T.D., Roberts, E.J., Soden, P.E., Auger, K.R., Mirguet, O., Doehner, K., Delwel, R., Burnett, A.K., Jeffrey, P., Drewes, G., Lee, K., Huntly, B.J., Kouzarides, T. Nature