CATH Domain 3zxrA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.590	Creatine Kinase; Chain A, domain 2
	3.30.590.10	Glutamine synthetase/guanido kinase, catalytic domain

Domain Context

CATH Clusters

Superfamily	Glutamine synthetase/guanido kinase, catalytic domain
Functional Family	Glutamine synthetase

Enzyme Information

6.3.1.2

Glutamine synthetase.

based on mapping to UniProt P9WN39

ATP + L-glutamate + NH(3) = ADP + phosphate + L-glutamine.

-!- Glutamine synthetase, which catalyzes the incorporation of ammonium into glutamate, is a key enzyme of nitrogen metabolism found in all domains of life. -!- Several types have been described, differing in their oligomeric structures and cofactor requirements.

UniProtKB Entries (1)

P9WN39

GLN1B_MYCTU

Mycobacterium tuberculosis H37Rv

Glutamine synthetase

PDB Structure

PDB	3ZXR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Trisubstituted Imidazoles as Mycobacterium Tuberculosis Glutamine Synthetase Inhibitors. Gising, J., Nilsson, M.T., Odell, L.R., Yahiaoui, S., Lindh, M., Iyer, H., Sinha, A.M., Srinivasa, B.R., Larhed, M., Mowbray, S.L., Karlen, A. J.Med.Chem.