CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.420 | Nucleotidyltransferase; domain 5 |
|
3.30.420.40 | ATPase, nucleotide binding domain |
Domain Context
CATH Clusters
| Superfamily | 3.30.420.40 |
| Functional Family | Ectonucleoside triphosphate diphosphohydrolase 1 |
Enzyme Information
| 3.6.1.5 |
Apyrase.
based on mapping to UniProt P97687
A nucleoside 5'-triphosphate + 2 H(2)O = a nucleoside 5'-phosphate + 2 phosphate.
-!- Apyrases are active against both di- and triphosphate nucleotides (NDPs and NTPs) and hydrolyze NTPs to nucleotide monophosphates (NMPs) in two distinct successive phosphate-releasing steps, with NDPs as intermediates. -!- They differ from ATPases, which specifically hydrolyze ATP, by hydrolyzing both ATP and ADP. -!- Most of the ecto-ATPases that occur on the cell surface and hydrolyze extracellular nucleotides belong to this enzyme family.
|
UniProtKB Entries (1)
| P97687 |
ENTP1_RAT
Rattus norvegicus
Ectonucleoside triphosphate diphosphohydrolase 1
|
PDB Structure
| PDB | 3ZX0 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystallographic evidence for a domain motion in rat nucleoside triphosphate diphosphohydrolase (NTPDase) 1.
J. Mol. Biol.
|
