CATH Domain 3zlqA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.70	Cathepsin D, subunit A; domain 1
	2.40.70.10	Acid Proteases

Domain Context

CATH Clusters

Superfamily	Acid Proteases
Functional Family	Beta-secretase 1

Enzyme Information

3.4.23.45

Memapsin 1.

based on mapping to UniProt Q9Y5Z0

Broad endopeptidase specificity. Cleaves Glu-Val-Asn-Leu-|-Asp-Ala-Glu- Phe in the Swedish variant of Alzheimer's amyloid precursor protein.

-!- Can cleave beta-amyloid precursor protein to form the amyloidogenic beta-peptide that is implicated in the pathology of Alzheimer's disease, but is not significantly expressed in human brain. -!- Belongs to peptidase family A1.

UniProtKB Entries (1)

Q9Y5Z0

BACE2_HUMAN

Homo sapiens

Beta-secretase 2

PDB Structure

PDB	3ZLQ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Beta-Secretase (Bace1) Inhibitors with High in Vivo Efficacy Suitable for Clinical Evaluation in Alzheimer'S Disease. Hilpert, H., Guba, W., Woltering, T.J., Wostl, W., Pinard, E., Mauser, H., Mayweg, A.V., Rogers-Evans, M., Humm, R., Krummenacher, D., Muser, T., Schnider, C., Jacobsen, H., Ozmen, L., Bergadano, A., Banner, D.W., Hochstrasser, R., Kuglstatter, A., David-Pierson, P., Fischer, H., Polara, A., Narquizian, R. J.Med.Chem.