CATH Domain 3zj6A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.20	Alpha-Beta Barrel
	3.20.20	TIM Barrel
	3.20.20.80	Glycosidases

Domain Context

CATH Clusters

Superfamily	Glycosidases
Functional Family	Beta-glucosidase 11

Enzyme Information

2.4.1.219	Vomilenine glucosyltransferase. based on mapping to UniProt Q9SPP9 UDP-glucose + vomilenine = UDP + raucaffricine. -!- The indole alkaloid raucaffricine accumulates during the culture of Rauvolfia cell suspensions.
3.2.1.125	Raucaffricine beta-glucosidase. based on mapping to UniProt Q9SPP9 Raucaffricine + H(2)O = D-glucose + vomilenine. -!- Highly specific; some other ajmalan glucoside alkaloids are hydrolyzed, more slowly.

UniProtKB Entries (1)

RG1_RAUSE

Rauvolfia serpentina

Raucaffricine-O-beta-D-glucosidase

PDB Structure

PDB	3ZJ6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Ligand Structures of Synthetic Deoxa-Pyranosylamines with Raucaffricine and Strictosidine Glucosidases Provide Structural Insights Into Their Binding and Inhibitory Behaviours. Xia, L., Lin, H., Staniek, A., Panjikar, S., Ruppert, M., Hilgers, P., Williardt, J., Rajendran, C., Wang, M., Warzecha, H., Jager, V., Stockigt, J. J.Enzyme.Inhib.Med.Chem.