CATH Domain 3zi0A03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1740	Rna Polymerase Sigma Factor; Chain: A
	1.10.1740.10	RNA polymerase sigma factor, region 2, helix turn helix motif

Domain Context

CATH Clusters

Superfamily	1.10.1740.10
Functional Family	1-deoxy-D-xylulose 5-phosphate reductoisomerase

Enzyme Information

1.1.1.267

1-deoxy-D-xylulose-5-phosphate reductoisomerase.

based on mapping to UniProt P9WNS1

2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH.

-!- The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis. -!- The mechanism has been shown to be a retroaldol/aldol reaction.

UniProtKB Entries (1)

P9WNS1

DXR_MYCTU

Mycobacterium tuberculosis H37Rv

1-deoxy-D-xylulose 5-phosphate reductoisomerase

PDB Structure

PDB	3ZI0
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Dxr Inhibition by Potent Mono- and Disubstituted Fosmidomycin Analogues. Jansson, A.M., Wieckowska, A., Bjorkelid, C., Yahiaoui, S., Sooriyaarachchi, S., Lindh, M., Bergfors, T., Dharavath, S., Desroses, M., Suresh, S., Andaloussi, M., Nikhil, R., Sreevalli, S., Srinivasa, B.R., Larhed, M., Jones, T.A., Karlen, A., Mowbray, S.L. J.Med.Chem.