CATH Domain 3wy7A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.640	Aspartate Aminotransferase; domain 2
	3.40.640.10	Type I PLP-dependent aspartate aminotransferase-like (Major domain)

Domain Context

CATH Clusters

Superfamily	Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family

Enzyme Information

2.3.1.47

8-amino-7-oxononanoate synthase.

based on mapping to UniProt A0QX65

Pimeloyl-[acyl-carrier protein] + L-alanine = 8-amino-7-oxononanoate + CO(2) + holo-[acyl-carrier protein].

-!- The enzyme catalyzes the decarboxylative condensation of L-alanine and pimeloyl-[acyl-carrier protein], a key step in the pathway for biotin biosynthesis. -!- Pimeloyl-CoA can be used with lower efficiency.

UniProtKB Entries (1)

A0QX65

BIOF_MYCS2

Mycolicibacterium smegmatis MC2 155

8-amino-7-oxononanoate synthase

PDB Structure

PDB	3WY7
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure and function of Mycobacterium smegmatis 7-keto-8-aminopelargonic acid (KAPA) synthase Fan, S.H., Li, D.F., Wang, D.C., Fleming, J., Zhang, H.T., Zhou, Y., Zhou, L., Zhou, J., Chen, T., Chen, G.J., Zhang, X.E., Bi, L.J. Int.J.Biochem.Cell Biol.