CATH Domain 3wx2A00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.170	Beta Complex
	2.170.150	Metal Binding Protein, Guanine Nucleotide Exchange Factor; Chain A
	2.170.150.20	Peptide methionine sulfoxide reductase.

Domain Context

CATH Clusters

Superfamily	Peptide methionine sulfoxide reductase.
Functional Family	Cereblon, isoform CRA_c

Enzyme Information

UniProtKB Entries (1)

CRBN_MOUSE

Mus musculus

Protein cereblon

PDB Structure

PDB	3WX2
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs Chamberlain, P.P., Lopez-Girona, A., Miller, K., Carmel, G., Pagarigan, B., Chie-Leon, B., Rychak, E., Corral, L.G., Ren, Y.J., Wang, M., Riley, M., Delker, S.L., Ito, T., Ando, H., Mori, T., Hirano, Y., Handa, H., Hakoshima, T., Daniel, T.O., Cathers, B.E. Nat.Struct.Mol.Biol.