CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.50 | Alpha/alpha barrel |
|
1.50.10 | Glycosyltransferase |
|
1.50.10.10 |
Domain Context
CATH Clusters
| Superfamily | 1.50.10.10 |
| Functional Family | Unsaturated chondroitin disaccharide hydrolase |
Enzyme Information
| 3.2.1.180 |
Unsaturated chondroitin disaccharide hydrolase.
based on mapping to UniProt Q8E372
Beta-D-4-deoxy-Delta(4)-GlcAp-(1->3)-beta-D-GalNAc6S + H(2)O = 5-dehydro- 4-deoxy-D-glucuronate + N-acetyl-beta-D-galactosamine-6-O-sulfate.
-!- The enzyme releases 4-deoxy-4,5-didehydro D-glucuronic acid or 4-deoxy-4,5-didehydro L-iduronic acid from chondroitin disaccharides, hyaluronan disaccharides and heparin disaccharides and cleaves both glycosidic (1->3) and (1->4) bonds. -!- It prefers the sulfated disaccharides to the unsulfated disaccharides.
|
UniProtKB Entries (1)
| Q8E372 |
UCDH_STRA3
Streptococcus agalactiae NEM316
Unsaturated chondroitin disaccharide hydrolase
|
PDB Structure
| PDB | 3WUX |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of unsaturated glucuronyl hydrolase mutant D115N/K370S from Streptococcus agalactiae
to be published
|
