CATH Domain 3wqqA03

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1740	Rna Polymerase Sigma Factor; Chain: A
	1.10.1740.10	RNA polymerase sigma factor, region 2, helix turn helix motif

Domain Context

CATH Clusters

Superfamily	1.10.1740.10
Functional Family	1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic

Enzyme Information

1.1.1.267

1-deoxy-D-xylulose-5-phosphate reductoisomerase.

based on mapping to UniProt O96693

2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + NADPH.

-!- The enzyme from several eubacteria, including Escherichia coli, forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis. -!- The mechanism has been shown to be a retroaldol/aldol reaction.

UniProtKB Entries (1)

O96693

DXR_PLAFX

Plasmodium falciparum HB3

1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic

PDB Structure

PDB	3WQQ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Binding Modes of Reverse Fosmidomycin Analogs toward the Antimalarial Target IspC. Konzuch, S., Umeda, T., Held, J., Hahn, S., Brucher, K., Lienau, C., Behrendt, C.T., Grawert, T., Bacher, A., Illarionov, B., Fischer, M., Mordmuller, B., Tanaka, N., Kurz, T. J.Med.Chem.