CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.12640 | Phosphopantoate/pantothenate synthetase |
Domain Context
CATH Clusters
| Superfamily | Phosphopantoate/pantothenate synthetase |
| Functional Family |
Enzyme Information
| 6.3.2.36 |
4-phosphopantoate--beta-alanine ligase.
based on mapping to UniProt Q5JIZ8
ATP + (R)-4-phosphopantoate + beta-alanine = AMP + diphosphate + (R)- 4'-phosphopantothenate.
-!- The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine, an essential cofactor of coenzyme A and acyl-carrier protein. -!- In bacteria and eukaryotes this conversion is performed by condensation with beta-alanine, followed by phosphorylation (EC 6.3.2.1 and EC 2.7.1.33, respectively). -!- In archaea the order of these two steps is reversed, and phosphorylation precedes condensation with beta-alanine. -!- The two archaeal enzymes that catalyze this conversion are EC 2.7.1.169 and this enzyme.
|
UniProtKB Entries (1)
| Q5JIZ8 |
PPS_THEKO
Thermococcus kodakarensis KOD1
4-phosphopantoate--beta-alanine ligase
|
PDB Structure
| PDB | 3WDL |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of phosphopantothenate synthetase from Thermococcus kodakarensis
Proteins
|