CATH Classification
Level | CATH Code | Description |
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1 | Mainly Alpha |
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1.10 | Orthogonal Bundle |
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1.10.600 | Farnesyl Diphosphate Synthase |
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1.10.600.10 | Farnesyl Diphosphate Synthase |
Domain Context
CATH Clusters
Superfamily | Farnesyl Diphosphate Synthase |
Functional Family | Squalene synthase |
Enzyme Information
2.5.1.21 |
Squalene synthase.
based on mapping to UniProt P37268
2 farnesyl diphosphate + NAD(P)H = squalene + 2 diphosphate + NAD(P)(+).
-!- This microsomal enzyme catalyzes the first committed step in the biosynthesis of sterols. -!- In the absence of NAD(P)H, presqualene diphosphate (PSPP) is accumulated. -!- When NAD(P)H is present, presqualene diphosphate does not dissociate from the enzyme during the synthesis of squalene from farnesyl diphosphate (FPP). -!- High concentrations of FPP inhibit the production of squalene but not of PSPP.
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UniProtKB Entries (1)
P37268 |
FDFT_HUMAN
Homo sapiens
Squalene synthase
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PDB Structure
PDB | 3WCJ |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Squalene synthase as a target for Chagas disease therapeutics.
Plos Pathog.
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