CATH Domain 3w86A02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.26	Dihydroorotate Dehydrogenase A; chain A, domain 2
	2.30.26.10	Dihydroorotate Dehydrogenase A, chain A, domain 2

Domain Context

CATH Clusters

Superfamily	Dihydroorotate Dehydrogenase A, chain A, domain 2
Functional Family	Dihydroorotate dehydrogenase (fumarate)

Enzyme Information

1.3.98.1

Dihydroorotate oxidase (fumarate).

based on mapping to UniProt Q4D3W2

(S)-dihydroorotate + fumarate = orotate + succinate.

-!- The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. -!- Molecular oxygen can replace fumarate in vitro. -!- Other class 1 dihydroorotate dehydrogenases use either NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor. -!- The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor. -!- Formerly EC 1.3.3.1.

UniProtKB Entries (1)

Q4D3W2

PYRD_TRYCC

Trypanosoma cruzi strain CL Brener

Dihydroorotate dehydrogenase (fumarate)

PDB Structure

PDB	3W86
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of Trypanosoma cruzi dihydroorotate dehydrogenase in complex with SH-1-96 Inaoka, D.K., Hashimoto, S., Rocha, J.R., Iida, M., Tabuchi, T., Lee, N., Matsuoka, S., Kuranaga, T., Shiba, T., Balogun, E.O., Sakamoto, K., Suzuki, S., Montanari, C.A., Nara, T., Aoki, T., Inoue, M., Honma, T., Tanaka, A., Harada, S., Kita, K. To be Published