CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.1400 |
Domain Context
CATH Clusters
| Superfamily | 3.40.50.1400 |
| Functional Family | Ferrochelatase |
Enzyme Information
| 4.99.1.1 |
Protoporphyrin ferrochelatase.
based on mapping to UniProt P22830
Protoheme + 2 H(+) = protoporphyrin + Fe(2+).
-!- The enzyme catalyzes the terminal step in the heme biosynthesis pathways of eukaryotes and Gram-negative bacteria.
|
UniProtKB Entries (1)
| P22830 |
HEMH_HUMAN
Homo sapiens
Ferrochelatase, mitochondrial
|
PDB Structure
| PDB | 3W1W |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Salicylic Acid induces mitochondrial injury by inhibiting ferrochelatase heme biosynthesis activity
Mol.Pharmacol.
|