CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.190 | D-Maltodextrin-Binding Protein; domain 2 |
|
3.40.190.10 | Periplasmic binding protein-like II |
Domain Context
CATH Clusters
| Superfamily | Periplasmic binding protein-like II |
| Functional Family |
Enzyme Information
| 2.3.1.16 |
Acetyl-CoA C-acyltransferase.
based on mapping to UniProt P27796
Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.
-!- The enzyme, found in both eukaryotes and in prokaryotes, is involved in degradation pathways such as fatty acid beta-oxidation. -!- The enzyme acts on 3-oxoacyl-CoAs to produce acetyl-CoA and an acyl- CoA shortened by two carbon atoms. -!- The reaction starts with the acylation of a nucleophilic cysteine at the active site by a 3-oxoacyl-CoA, with the concomitant release of acetyl-CoA. -!- In the second step the acyl group is transferred to CoA. -!- Most enzymes have a broad substrate range for the 3-oxoacyl-CoA. -!- cf. EC 2.3.1.9.
|
UniProtKB Entries (2)
| P0AEX9 |
MALE_ECOLI
Escherichia coli K-12
Maltose/maltodextrin-binding periplasmic protein
|
| P27796 |
THIK_YEAST
Saccharomyces cerevisiae S288C
3-ketoacyl-CoA thiolase, peroxisomal
|
PDB Structure
| PDB | 3W15 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of peroxisomal targeting signal-2 bound to its receptor complex Pex7p-Pex21p
Nat.Struct.Mol.Biol.
|
