CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.200 | Tumour Suppressor Smad4 |
|
2.60.200.40 |
Domain Context
CATH Clusters
| Superfamily | 2.60.200.40 |
| Functional Family | Sphingosine kinase 1 |
Enzyme Information
| 2.7.1.91 |
Sphingosine kinase.
based on mapping to UniProt Q9NYA1
ATP + a sphingoid base = ADP + a sphingoid base 1-phosphate.
-!- The enzyme is involved in the production of sphingolipid metabolites. -!- It phosphorylates various sphingoid long-chain bases, such as sphingosine, D-erythro-dihydrosphingosine (sphinganine), phytosphingosine (4-hydroxysphinganine), 4-hydroxy-8-sphingenine, 4,8-sphingadienine and D-threo-dihydrosphingosine and L-threo- dihydrosphingosine. -!- The exact substrate range depends on the species.
|
| 2.3.1.- |
Transferring groups other than amino-acyl groups.
based on mapping to UniProt Q9NYA1
|
UniProtKB Entries (1)
| Q9NYA1 |
SPHK1_HUMAN
Homo sapiens
Sphingosine kinase 1
|
PDB Structure
| PDB | 3VZC |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Molecular basis of sphingosine kinase 1 substrate recognition and catalysis.
Structure
|
