CATH Domain 3vteA03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.462	Vanillyl-alcohol Oxidase; Chain A, domain 3
	3.40.462.20

Domain Context

CATH Clusters

Superfamily	3.40.462.20
Functional Family

Enzyme Information

1.21.3.7

Tetrahydrocannabinolic acid synthase.

based on mapping to UniProt Q8GTB6

Cannabigerolate + O(2) = Delta(9)-tetrahydrocannabinolate + H(2)O(2).

-!- The cofactor is covalently bound. -!- Part of the cannabinoids biosynthetic pathway in the plant Cannabis sativa. -!- The enzyme can also convert cannabinerolate (the (Z)-isomer of cannabigerolate) to Delta(9)-THCA with lower efficiency. -!- The traditional numbering called Delta(9)-tetrahydrocannabinolate, Delta(1)-tetrahydrocannabinolate. -!- Systematic peripheral numbering is now recommended.

UniProtKB Entries (1)

Q8GTB6

THCAS_CANSA

Cannabis sativa

Tetrahydrocannabinolic acid synthase

PDB Structure

PDB	3VTE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure and function of 1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa Shoyama, Y., Tamada, T., Kurihara, K., Takeuchi, A., Taura, F., Arai, S., Blaber, M., Shoyama, Y., Morimoto, S., Kuroki, R. J.Mol.Biol.