CATH Domain 3vteA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.43	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 2
	3.30.43.10	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2

Domain Context

CATH Clusters

Superfamily	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2
Functional Family	Berberine bridge enzyme-like 15

Enzyme Information

1.21.3.7

Tetrahydrocannabinolic acid synthase.

based on mapping to UniProt Q8GTB6

Cannabigerolate + O(2) = Delta(9)-tetrahydrocannabinolate + H(2)O(2).

-!- The cofactor is covalently bound. -!- Part of the cannabinoids biosynthetic pathway in the plant Cannabis sativa. -!- The enzyme can also convert cannabinerolate (the (Z)-isomer of cannabigerolate) to Delta(9)-THCA with lower efficiency. -!- The traditional numbering called Delta(9)-tetrahydrocannabinolate, Delta(1)-tetrahydrocannabinolate. -!- Systematic peripheral numbering is now recommended.

UniProtKB Entries (1)

Q8GTB6

THCAS_CANSA

Cannabis sativa

Tetrahydrocannabinolic acid synthase

PDB Structure

PDB	3VTE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure and function of 1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa Shoyama, Y., Tamada, T., Kurihara, K., Takeuchi, A., Taura, F., Arai, S., Blaber, M., Shoyama, Y., Morimoto, S., Kuroki, R. J.Mol.Biol.