CATH Classification

Domain Context

CATH Clusters

Superfamily Peroxidase, domain 2
Functional Family Catalase-peroxidase

Enzyme Information

1.11.1.21
Catalase peroxidase.
based on mapping to UniProt O59651
(1) Donor + H(2)O(2) = oxidized donor + 2 H(2)O. (2) 2 H(2)O(2) = O(2) + 2 H(2)O.
-!- Differs from EC 1.11.1.7, peroxidase, in having a relatively high catalase (EC 1.11.1.6) activity with H(2)O(2) as donor, releasing O(2); both activities use the same heme active site. -!- In Mycobacterium tuberculosis it is responsible for activation of the commonly used antitubercular drug, isoniazid.

UniProtKB Entries (1)

O59651
KATG2_HALMA
Haloarcula marismortui ATCC 43049
Catalase-peroxidase 2

PDB Structure

PDB 3VLL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure and Kinetics Studies on Ser305Ala variant of KatG from HALOARCULA MARISMORTUI and its Complexes with Inhibitor SHA
Sato, T., Higuchi, W., Yoshimatsu, K., Fujiwara, T.
To be Published