CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family |
Enzyme Information
| 3.6.4.13 |
RNA helicase.
based on mapping to UniProt P03587
ATP + H(2)O = ADP + phosphate.
-!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).
|
| 2.7.7.- |
Nucleotidyltransferases.
based on mapping to UniProt P03587
|
| 2.7.7.48 |
RNA-directed RNA polymerase.
based on mapping to UniProt P03587
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.
|
| 2.1.1.- |
Methyltransferases.
based on mapping to UniProt P03587
|
UniProtKB Entries (1)
| P03587 |
RDRP_TOML
Tobacco mosaic virus strain tomato/L
Replicase large subunit
|
PDB Structure
| PDB | 3VKW |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of the superfamily 1 helicase from tomato mosaic virus
J.Virol.
|