CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.930 | BirA Bifunctional Protein; domain 2 |
|
3.30.930.10 | Bira Bifunctional Protein; Domain 2 |
Domain Context
CATH Clusters
| Superfamily | Bira Bifunctional Protein; Domain 2 |
| Functional Family | Serine--tRNA ligase, cytoplasmic |
Enzyme Information
| 6.1.1.11 |
Serine--tRNA ligase.
based on mapping to UniProt P49591
(1) ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser). (2) ATP + L-serine + tRNA(Sec) = AMP + diphosphate + L-seryl-tRNA(Sec).
-!- This enzyme also recognizes tRNA(Sec), the special tRNA for selenocysteine, and catalyzes the formation of L-seryl-tRNA(Sec), the substrate for EC 2.9.1.1.
|
UniProtKB Entries (1)
| P49591 |
SYSC_HUMAN
Homo sapiens
Serine--tRNA ligase, cytoplasmic
|
PDB Structure
| PDB | 3VBB |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Unique domain appended to vertebrate tRNA synthetase is essential for vascular development.
Nat Commun
|
