CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.167 | Regulator of G-protein Signalling 4; domain 2 | |
1.10.167.10 | Regulator of G-protein Signalling 4, domain 2 |
Domain Context
CATH Clusters
Superfamily | Regulator of G-protein Signalling 4, domain 2 |
Functional Family |
Enzyme Information
2.7.11.15 |
[Beta-adrenergic-receptor] kinase.
based on mapping to UniProt P25098
ATP + [beta-adrenergic receptor] = ADP + [beta-adrenergic receptor] phosphate.
-!- Acts on the agonist-occupied form of the receptor; also phosphorylates rhodopsin, but more slowly. -!- Does not act on casein or histones. -!- Inhibited by Zn(2+) and digitonin but is unaffected by cyclic-AMP (cf. EC 2.7.11.14 and EC 2.7.11.16). -!- Formerly EC 2.7.1.126.
|
UniProtKB Entries (2)
P63212 |
GBG2_BOVIN
Bos taurus
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
|
P25098 |
ARBK1_HUMAN
Homo sapiens
Beta-adrenergic receptor kinase 1
|
PDB Structure
PDB | 3V5W |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility.
Acs Chem.Biol.
|