CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.120 | 6 Propeller |
|
2.120.10 | Neuraminidase |
|
2.120.10.30 | TolB, C-terminal domain |
Domain Context
CATH Clusters
| Superfamily | TolB, C-terminal domain |
| Functional Family |
Enzyme Information
| 4.3.3.2 |
Strictosidine synthase.
based on mapping to UniProt P68175
3-alpha-(S)-strictosidine + H(2)O = tryptamine + secologanin.
-!- Catalyzes a a Pictet-Spengler reaction between the aldehyde group of secologanin and the amino group of tryptamine. -!- Involved in the biosynthesis of the monoterpenoid indole alkaloids.
|
UniProtKB Entries (1)
| P68175 |
STSY_RAUSE
Rauvolfia serpentina
Strictosidine synthase
|
PDB Structure
| PDB | 3V1S |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Scaffold Tailoring by a Newly Detected Pictet-Spenglerase Activity of Strictosidine Synthase: From the Common Tryptoline Skeleton to the Rare Piperazino-indole Framework
J.Am.Chem.Soc.
|