CATH Domain 3v1sA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.120	6 Propeller
	2.120.10	Neuraminidase
	2.120.10.30	TolB, C-terminal domain

Domain Context

CATH Clusters

Superfamily	TolB, C-terminal domain
Functional Family

Enzyme Information

4.3.3.2

Strictosidine synthase.

based on mapping to UniProt P68175

3-alpha-(S)-strictosidine + H(2)O = tryptamine + secologanin.

-!- Catalyzes a a Pictet-Spengler reaction between the aldehyde group of secologanin and the amino group of tryptamine. -!- Involved in the biosynthesis of the monoterpenoid indole alkaloids.

UniProtKB Entries (1)

P68175

STSY_RAUSE

Rauvolfia serpentina

Strictosidine synthase

PDB Structure

PDB	3V1S
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Scaffold Tailoring by a Newly Detected Pictet-Spenglerase Activity of Strictosidine Synthase: From the Common Tryptoline Skeleton to the Rare Piperazino-indole Framework Wu, F., Zhu, H., Sun, L., Rajendran, C., Wang, M., Ren, X., Panjikar, S., Cherkasov, A., Zou, H., Stockigt, J. J.Am.Chem.Soc.