CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family | Thymidylate kinase |
Enzyme Information
| 2.7.4.9 |
dTMP kinase.
based on mapping to UniProt Q9HZN8
ATP + dTMP = ADP + dTDP.
|
UniProtKB Entries (1)
| Q9HZN8 |
KTHY_PSEAE
Pseudomonas aeruginosa PAO1
Thymidylate kinase
|
PDB Structure
| PDB | 3UWO |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure guided development of novel thymidine mimetics targeting Pseudomonas aeruginosa thymidylate kinase: from hit to lead generation.
J.Med.Chem.
|