CATH Domain 3ue8A02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.640	Aspartate Aminotransferase; domain 2
	3.40.640.10	Type I PLP-dependent aspartate aminotransferase-like (Major domain)

Domain Context

CATH Clusters

Superfamily	Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family

Enzyme Information

2.6.1.7	Kynurenine--oxoglutarate transaminase. based on mapping to UniProt Q8N5Z0 L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate. -!- Also acts on 3-hydroxykynurenine. -!- The product 4-(2-aminophenyl)-2,4-dioxobutanoate is converted into kynurenate by a spontaneous reaction.
2.6.1.39	2-aminoadipate transaminase. based on mapping to UniProt Q8N5Z0 L-2-aminoadipate + 2-oxoglutarate = 2-oxoadipate + L-glutamate.

UniProtKB Entries (1)

AADAT_HUMAN

Homo sapiens

Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

PDB Structure

PDB	3UE8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia. Dounay, A.B., Anderson, M., Bechle, B.M., Campbell, B.M., Claffey, M.M., Evdokimov, A., Evrard, E., Fonseca, K.R., Gan, X., Ghosh, S., Hayward, M.M., Horner, W., Kim, J.Y., McAllister, L.A., Pandit, J., Paradis, V., Parikh, V.D., Reese, M.R., Rong, S., Salafia, M.A., Schuyten, K., Strick, C.A., Tuttle, J.B., Valentine, J., Wang, H., Zawadzke, L.E., Verhoest, P.R. ACS Med Chem Lett