CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
6 | Special |
|
6.10 | Helix non-globular |
|
6.10.250 | Single alpha-helices involved in coiled-coils or other helix-helix interfaces |
|
6.10.250.2390 |
Domain Context
CATH Clusters
| Superfamily | 6.10.250.2390 |
| Functional Family |
Enzyme Information
| 2.1.1.43 |
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q03164
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].
|
UniProtKB Entries (1)
| Q03164 |
KMT2A_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase 2A
|
PDB Structure
| PDB | 3U88 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription.
Nature
|
