CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.300 | P-loop containing nucleotide triphosphate hydrolases |
Domain Context
CATH Clusters
| Superfamily | P-loop containing nucleotide triphosphate hydrolases |
| Functional Family | Bifunctional polynucleotide phosphatase/kinase |
Enzyme Information
| 2.7.1.78 |
Polynucleotide 5'-hydroxyl-kinase.
based on mapping to UniProt Q9JLV6
ATP + 5'-dephospho-DNA = ADP + 5'-phospho-DNA.
-!- Also acts on 5'-dephospho-RNA 3'-mononucleotides.
|
| 3.1.3.32 |
Polynucleotide 3'-phosphatase.
based on mapping to UniProt Q9JLV6
A 3'-phosphopolynucleotide + H(2)O = a polynucleotide + phosphate.
-!- Also hydrolyzes nucleoside 2'-, 3'- and 5'-monophosphates, but only 2'- and 3'-phosphopolynucleotides.
|
UniProtKB Entries (1)
| Q9JLV6 |
PNKP_MOUSE
Mus musculus
Bifunctional polynucleotide phosphatase/kinase
|
PDB Structure
| PDB | 3U7G |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for the phosphatase activity of polynucleotide kinase/phosphatase on single- and double-stranded DNA substrates.
Proc.Natl.Acad.Sci.USA
|
