CATH Domain 3tzaA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.190	D-Maltodextrin-Binding Protein; domain 2
	3.40.190.10	Periplasmic binding protein-like II

Domain Context

CATH Clusters

Superfamily	Periplasmic binding protein-like II
Functional Family	Glutamate receptor ionotropic, kainate 2

Enzyme Information

UniProtKB Entries (1)

GRIA2_RAT

Rattus norvegicus

Glutamate receptor 2

PDB Structure

PDB	3TZA
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: synthesis, resolution, pharmacology, and crystal structure Szymanska, E., Frydenvang, K., Contreras-Sanz, A., Pickering, D.S., Frola, E., Serafimoska, Z., Nielsen, B., Kastrup, J.S., Johansen, T.N. J.Med.Chem.